bakerlab.orgMain - The Baker Lab

Institute for Protein Design Rosetta@home Foldit Robetta GREMLIN The Baker Lab Part of the UW Institute for Protein Design Menu Publications Members Current Former Community In the lab Beyond the lab Photos In the Media Contact Links Welcome! We seek to understand the fundamental principles underlying protein structure and function, to encode these principles in the Rosetta computer program, and to use them to create a new world of de novo designed proteins to address 21st century challenges in health and technology. In all cases, we start entirely from first principles; we do not re-engineer native proteins. By iterating between computation and experiment, we continually improve our design methodology. We are always looking for talented, enthusiastic and diverse scientists to join our efforts! Our philosophy is that the more closely interacting a research group is, the better the science and the more fun overall. We are located within the Institute for Protein Design at the University of Washington in Seattle. Click here to learn about available child-care options. Current research areas Designing molecular switches, enzymes, and motors Designing delivery vehicles for targeted intracellular delivery of biologics Designing smart protein therapeutics that carry out logic operations in the body Developing methods for designing high-affinity binders to arbitrary small molecule and protein targets Designing membrane-permeable macrocyclic peptide therapeutics Generating novel hybrid materials through designed biomineralization Deep learning for protein structure refinement Latest Rosetta’s role in fighting coronavirus April 18, 2020 De novo design of protein logic gates April 2, 2020 Designing shape-shifting proteins March 18, 2020 SCI-STEM Symposium 2020 January 22, 2020 Congrats, Dr Nattermann! October 30, 2019 Neville wins HHMI Hanna Gray Fellowship! September 17, 2019 Copyright 2019 Baker Lab...